Our research

 

 

Structure, Function, Regulation: We aim to dissect the molecular machinery controlling the physiological trafficking of neuronal calcium channels to the plasma membrane, and how metabolic defects associated with a number of chronic disorders such as type 2 diabetes hijack this machinery eventually leading to neuronal pathologies such as epilepsy or neuropathic pain.

 

Genetic: We aim to analyze the functional consequence of genetic mutations in the calcium channel itself, or in the trafficking machinery units, providing a genetic-functional link to inherited neuronal disorders.

 

Pharmacology: Ultimately, we wish to translate new insights into the development of novel therapeutic avenues.