G-protein Regulation of Neuronal Calcium Channels: Back to the Future

Neuronal voltage-gated calcium channels have evolved as one of the most important players for calcium entry into presynaptic endings responsible for the release of neurotransmitter. In turn, and in order to fine tune synaptic activity and neuronal communication, numerous neurotransmitters exert a potent negative autocrine and/or paracrine control over the calcium signal provided by G-protein-coupled receptors. This regulation pathway is also extensively exploited for therapeutic purposes, for instance in the treatment of neuropathic pain by morphine. Here, we revisit how G-protein coupled receptors modulate neuronal calcium channel activity and explore new considerations with regards to the molecular physiology and physiopathology. Find the manuscript here.